BROMINE CHLORIDE (BrCl) → HCID 11598674、化合物
反応式
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[C:16][C:17]2[C:22]([Br:23])=[CH:21][C:20]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)=[CH:19][N:18]=2)=[CH:11][CH:10]=1)(=O)=O.[CH3:31][CH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.BrCl>>[Br:23][C:22]1[C:17]([C:16]#[C:15][C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][N:35]3[CH2:36][CH2:37][CH:32]([CH3:31])[CH2:33][CH2:34]3)=[CH:10][CH:11]=2)=[N:18][CH:19]=[C:20]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[CH:21]=1参加物
4
実験手順
The product was obtained analogously to Example 7.1g starting from 2-{4-[3-bromo-5-(4-chlorophenyl)pyridin-2-ylethynyl]phenoxy}ethyl methanesulfonate and 4-methylpiperidine. Yield: 0.15 g (88% of theoretical); C27H26BrClN2O (M=509.865); calc.: molpeak (M+H)+: 509/511/513 (BrCl); found: molpeak (M+H)+: 509/511/513 (BrCl); HPLC-MS: 6.11 minutes (method A).