Tetrabutylammonium Fluoride → 3-Bromo-4-ethynylbiphenyl

HRID 735157ノート

反応式

HRID 735157 の反応式
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Br:19][C:20]1[CH:21]=[C:22]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:23]=[CH:24][C:25]=1[C:26]#[C:27][Si](C(C)(C)C)(C)C>C1COCC1>[Br:19][C:20]1[CH:21]=[C:22]([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:23]=[CH:24][C:25]=1[C:26]#[CH:27]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 68817863(3-Bromobiphenyl-4-ylethynyl)-tert-butyldimethylsilane

生成物 1

HCID 860607363-Bromo-4-ethynylbiphenyl

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

1.99 mL (1.99 mmol) of a 1M tetrabutylammonium fluoride solution in THF is added batchwise at 5° C. to a solution of 495 mg (1.33 mmol) of (3-bromobiphenyl-4-ylethynyl)-tert-butyldimethylsilane in 8 mL of anhydrous THF. The reaction mixture is stirred for another 30 minutes at ambient temperature and evaporated down. The residue is combined with diethyl ether and water and the organic phase is dried over sodium sulfate. Yield: 0.34 g (99% of theory); C14H9Br (M=257.12); calc.: molecular ion peak (M−H)−: 255/257 (Br); found: molecular ion peak (M−H)−: 255/257 (Br).

後処理

  1. customevaporated down
  2. dry with materialthe organic phase is dried over sodium sulfate

出典と根拠

ORDレコード
ord-ce0087346a914ada91830205f2a9702d
出典データセット
uspto-grants-2009_09
特許番号
US07592373B2

反応ノート

読み込み中…