Tetrahydrofuran → 1-(2-Benzyl-3-phenyl-2h-indazol-7-yl)ethanone

HRID 735468ノート

反応式

HRID 735468 の反応式
[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10](C(C(O)=O)=CC=[CH:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li][CH3:27].[CH2:28]1[CH2:32][O:31][CH2:30][CH2:29]1>>[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:28]([C:32](=[O:31])[CH3:27])=[CH:29][CH:30]=[CH:14]2)=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 8028TetrahydrofuranHCID 67021115HCID 67021115、化合物HCID 178418348HCID 178418348、化合物

生成物 1

HCID 670210041-(2-Benzyl-3-phenyl-2h-indazol-7-yl)ethanone

実験手順

2-Benzyl-3-phenyl-2H-indazole-7-carboxylic acid (0.5 mmol, 160 mg, see preparation of Example 518) was dissolved in 5 ml of dry THF at 0° C. Two milliliters (2 ml) of MeLi (1.6M solution in THF) were added dropwise and the mixture was stirred overnight at room temperature. The reaction mixture was quenched with aq NH4Cl solution and the product was extracted with EtOAc, and then flash column chromatography (SiO2, dichloromethane as an eluant) afforded 1-(2-benzyl-3-phenyl-2H-indazol-7-yl)ethanone in 61% yleld.

後処理

  1. customThe reaction mixture was quenched with aq NH4Cl solution
  2. extractionthe product was extracted with EtOAc

出典と根拠

ORDレコード
ord-3285cf337324464392ab5406dba0c327
出典データセット
uspto-grants-2009_09
特許番号
US07592363B2

反応ノート

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