p-Toluenesulfonic acid → HCID 67021327、化合物
反応式
[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:11]([C:23](O)([CH3:25])[CH3:24])=[CH:12][CH:13]=[CH:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC1C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:11]([C:23]([CH3:25])=[CH2:24])=[CH:12][CH:13]=[CH:14]2)=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
反応条件
- 温度
- 110 °C
実験手順
Fifty milligrams (50 mg; 0.15 mmol) of 2-(2-benzyl-3-phenyl-2H-indazol-7-yl)propan-2-ol (Example 520) were dissolved in 2 ml of toluene followed by the addition of 11 mg of TsOH. The mixture was heated at 110° C. for 1 hour. After cooling, the resulting solution was filtered through SiO2 plug affording, after evaporation, 45 mg of pure 2-benzyl-7-isopropenyl-3-phenyl-2H-indazole. Yield: 94%.