HCID 67021327、化合物 → 2-benzyl-7-isopropyl-3-phenyl-2H-indazole

HRID 735471ノート

反応式

HRID 735471 の反応式
[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:11]([C:23]([CH3:25])=[CH2:24])=[CH:12][CH:13]=[CH:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.O=[Pt]=O>[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:11]([CH:23]([CH3:25])[CH3:24])=[CH:12][CH:13]=[CH:14]2)=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 67021327HCID 67021327、化合物

生成物 1

HCID 670211842-benzyl-7-isopropyl-3-phenyl-2H-indazole

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

Thirty milligrams (30 mg; 0.092 mmol) of 2-benzyl-7-isopropenyl-3-phenyl-2H-indazole (Example 521) were dissolved in 2 ml of dry ethanol followed by the addition of 30 mg of PtO2. The reaction mixture was stirred under H2 atmosphere at room temperature for 2 hours, then filtered and the EtOH evaporated. Flash column chromatography (SiO2, dichloromethane/heptane, 1:1, as an eluant) afforded 2-benzyl-7-isopropyl-3-phenyl-2H-indazole in 80% yleld.

後処理

  1. filtrationfiltered
  2. customthe EtOH evaporated

出典と根拠

ORDレコード
ord-c273b8eb44dd43bba06e8d9d0ba91261
出典データセット
uspto-grants-2009_09
特許番号
US07592363B2

反応ノート

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