Sodium Hydroxide → 5-(4-Boronophenyl)pentanoic acid

反応式

B(C1C=CC(CCCC(O)=O)=CC=1)(O)O.CC1(C)C[O:21][B:20]([C:23]2[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[CH:25][CH:24]=2)[O:19]C1.[OH-].[Na+]>>[B:20]([C:23]1[CH:24]=[CH:25][C:26]([CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[CH:27][CH:28]=1)([OH:21])[OH:19]

参加物

反応物 3

HCID 14798Sodium Hydroxide

HCID 578425984-(4-Boronophenyl)butanoic acid

HCID 578428175-(4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)pentanoic acid

生成物 1

HCID 578427605-(4-Boronophenyl)pentanoic acid収率 76.1%

実験手順

Using a procedure analogous to that used to prepare 2B, 5A (429 mg, 1.48 mmol) was reacted with NaOH to afford 5B (250 mg, 76%) as an off-white solid.

出典と根拠

ORDレコード: ord-48ef29e38e2243e59200679cc9e18051
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07592331B2

反応ノート

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