Sodium borohydride → 1-(4-Bromophenyl)butan-2-ol
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:12])[CH2:10][CH3:11])=[CH:4][CH:3]=1.[BH4-].[Na+]>CO.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([OH:12])[CH2:10][CH3:11])=[CH:6][CH:7]=1参加物
5
実験手順
To a solution of 70B (478 mg, 2.1 mmol) in 5 mL MeOH at 0° C., was added NaBH4 (110 mg, 2.98 mmol). The solution was stirred at rt for 30 min, then was diluted with EtOAc and washed with H2O and brine, dried (Na2SO4) and concentrated. Purification via flash chromatography (0-30% EtOAc/hexanes) afforded 70C (460 mg, 96%). MS (ESI) m/z 221.2 (M-OH)+.
後処理
- washwashed with H2O and brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
- customPurification via flash chromatography (0-30% EtOAc/hexanes)
出典と根拠
- ORDレコード
- ord-d4fa01af1dda438c93d87216ef8a2f6e
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592331B2
反応ノート
読み込み中…