Ethyl Acetate → (R)-2-(4-bromophenyl)propan-1-ol
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([CH3:12])[C:9](O)=[O:10])=[CH:4][CH:3]=1.CCOC(C)=O>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]([CH3:12])[CH2:9][OH:10])=[CH:6][CH:7]=1参加物
4
実験手順
To a solution of 76C (95 mg, 0.42 mmol) in THF (3 mL) at 0° C., was added BH3 (1M in THF, 0.4 mL, 4 mmol). The mixture was stirred rt for 16 h. EtOAc (20 mL) was added, and the organic phase washed with 1M H3PO4, sat. NaHCO3 and brine, dried (Na2SO4), and concentrated to give 76D (90 mg, 100%). MS (ESI) m/z 197.0 (M−H2O+H)+.
後処理
- washthe organic phase washed with 1M H3PO4, sat. NaHCO3 and brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a9617d23127c494ebba9c3869d79d6b0
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592331B2
反応ノート
読み込み中…