Water → 4-[(2-Hydroxyethyl)(methyl)amino]benzoic acid
反応式
[OH:1][CH2:2][CH2:3][N:4]([CH3:16])[C:5]1[CH:15]=[CH:14][C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][CH:6]=1.[OH-].[Na+].O>CO>[OH:1][CH2:2][CH2:3][N:4]([CH3:16])[C:5]1[CH:15]=[CH:14][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1参加物
5
実験手順
To a solution (10 ml) of ethyl 4-[(2-hydroxyethyl) (methyl)amino]benzoate (500 mg, 2.24 mmol) in methanol was added 1M aqueous sodium hydroxide solution (10 ml), and the mixture was stirred at room temperature for 3 hrs. Water was added to the reaction mixture, and the mixture was washed with diethyl ether. 1M Hydrochloric acid (10 ml) was added, and the mixture was extracted with dichloromethane and concentrated under reduced pressure to give the title compound (119 mg, 27%) as a white solid.
後処理
- washthe mixture was washed with diethyl ether
- addition1M Hydrochloric acid (10 ml) was added
- extractionthe mixture was extracted with dichloromethane
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-2a0c8d71fada4cf9845d226ce55136b9
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592453B2
反応ノート
読み込み中…