Sodium Azide → Methyl 4-(azidomethyl)-1-naphthoate
反応式
Br[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1.[N-:17]=[N+:18]=[N-:19].[Na+]>CS(C)=O.O>[N:17]([CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1)=[N+:18]=[N-:19]参加物
5
実験手順
To a solution of methyl 4-(bromomethyl)-1-naphthoate (30 g, 0.107 mol) in anhydrous DMSO (300 mL) was added NaN3 portion wise (14 g, 0.215 mol) at 0° C. and stirred at rt for 16 h. Then the reaction mixture was diluted with water (500 mL), extracted with EtOAc (2×250 mL), washed with water, brine and dried over MgSO4. The solvent was removed under vacuum to give methyl 4-(azidomethyl)-1-naphthoate (20 g, 77%).
後処理
- extractionextracted with EtOAc (2×250 mL)
- washwashed with water, brine
- dry with materialdried over MgSO4
- customThe solvent was removed under vacuum
出典と根拠
- ORDレコード
- ord-1603d0d10eef4ff58108e96f77f08116
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07592477B2
反応ノート
読み込み中…