(4aS,8aS)-1-benzyl-4-(phenylamino)octahydroquinolin-4a(2H)-ol → HCID 68154084、化合物
反応式
C([N:8]1[C@@H:17]2[C@:12]([OH:18])([CH2:13][CH2:14][CH2:15][CH2:16]2)[CH:11]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[C:20]1([NH:19][CH:11]2[C@:12]3([OH:18])[C@H:17]([CH2:16][CH2:15][CH2:14][CH2:13]3)[NH:8][CH2:9][CH2:10]2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
To a mixture of (4aS,8aS)-1-benzyl-4-(phenylamino)octahydroquinolin-4a(2H)-ol (0.280 g, 0.832 mmol) in MeOH (5 mL) was added NH4COOH (0.840 g, 13.3 mmol) and 10% Pd/C (0.280 g). The resulting mixture was heated at 60° C. for several hours. The reaction was cooled to rt, filtered through a syringe filter, washed with EtOH, and concentrated to give the title compound. LRMS M+H calc'd: 247.34. found 247.34