Morpholine → 3-Fluoro-N-methyl-4-morpholin-4-yl-5-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide

HRID 736222

反応式

HRID 736222 の反応式
[F:1][C:2]1[CH:3]=[C:4]([S:27]([NH:30][CH3:31])(=[O:29])=[O:28])[CH:5]=[C:6]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=[O:10])[C:7]=1F.[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1>>[F:1][C:2]1[CH:3]=[C:4]([S:27]([NH:30][CH3:31])(=[O:28])=[O:29])[CH:5]=[C:6]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:18]=[CH:19][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:22]=3)[CH2:13][CH2:12]2)=[O:10])[C:7]=1[N:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1

参加物

3

反応物 2

HCID 8083MorpholineHCID 597935643,4-Difluoro-N-methyl-5-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide

生成物 1

HCID 688441643-Fluoro-N-methyl-4-morpholin-4-yl-5-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide

実験手順

The title compound was prepared according to the procedure described for example 202 from 3,4-Difluoro-N-methyl-5-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide (example CC) and morpholine to yield the title compound as a colourless foam, MS (m/e): 531.1 (M+H, 100%).

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-77f36718b5314807a88821ba34a56eed
出典データセット
uspto-grants-2009_09
特許番号
US07595314B2

関連ノート

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