Tetrahydrofurfurylamine → Rac-{5-methanesulfonyl-2-[(tetrahydro-furan-2-ylmethyl)-amino]-phenyl}-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

HRID 736246

反応式

HRID 736246 の反応式
I[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)[CH2:16][CH2:15]1)=[O:13].[CH2:30]([NH2:36])[CH:31]1[O:35][CH2:34][CH2:33][CH2:32]1>>[CH3:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:36][CH2:30][CH:31]2[CH2:32][CH2:33][CH2:34][O:35]2)=[C:3]([C:12]([N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[O:13])[CH:4]=1)(=[O:10])=[O:9]

参加物

3

反応物 2

HCID 253298TetrahydrofurfurylamineHCID 59793691(2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone

生成物 1

HCID 68840286Rac-{5-methanesulfonyl-2-[(tetrahydro-furan-2-ylmethyl)-amino]-phenyl}-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone収率 28%

実験手順

The title compound was prepared according to the procedure described for example 301 from (2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CK) and tetrahydrofurfurylamine (28% yield, MS (m/e): 512.4 (M+H, 100%)

出典と根拠

ORDレコード
ord-eb6856f08a8b43b297d4e9ad5fc2f2d3
出典データセット
uspto-grants-2009_09
特許番号
US07595314B2

関連ノート

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