1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one → (3-Nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine

HRID 736309

反応式

HRID 736309 の反応式
[N+]([O-])(O)=O.[N+:5]([C:8]1[CH:9]=[C:10]([NH:14][C:15]([NH2:17])=[NH:16])[CH:11]=[CH:12][CH:13]=1)([O-:7])=[O:6].CN(C)[CH:20]=[CH:21][C:22]([C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1)=O>>[N+:5]([C:8]1[CH:9]=[C:10]([NH:14][C:15]2[N:17]=[C:22]([C:24]3[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=3)[CH:21]=[CH:20][N:16]=2)[CH:11]=[CH:12][CH:13]=1)([O-:7])=[O:6]

参加物

3

反応物 2

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneHCID 1785125133-Nitrophenylguanidine Nitrate

生成物 1

HCID 9860872(3-Nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine収率 69.7%

実験手順

3-Nitrophenyl-guanidine nitrate (28 g, 0.12 mol) and 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one (16.9 g, 0.09 mol) were reacted according to the same procedure as Step 1.3 of Preparation 1 to give N-(3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine (18.4 g).

後処理

  1. customaccording to the same procedure as Step 1.3 of Preparation 1

出典と根拠

ORDレコード
ord-18ee62cb361345d79978b33f89b667b2
出典データセット
uspto-grants-2009_09
特許番号
US07595323B2

関連ノート

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