1,2-Benzisothiazol-3(2H)-one → 3-Oxo-3H-benzo[d]isothiazole-2-carboxylic acid propylamide

HRID 736617

反応式

HRID 736617 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3](=[O:10])[NH:2]1.[CH2:11]([N:14]=[C:15]=[O:16])[CH2:12][CH3:13]>>[CH2:11]([NH:14][C:15]([N:2]1[C:3](=[O:10])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1]1)=[O:16])[CH2:12][CH3:13]

参加物

3

反応物 2

HCID 175201,2-Benzisothiazol-3(2H)-oneHCID 61033Propyl isocyanate

生成物 1

HCID 114362953-Oxo-3H-benzo[d]isothiazole-2-carboxylic acid propylamide

実験手順

Following the synthetic procedure of 6a as described in Example 1, compound 6b (77% yield) was synthesized from benzo[d]isothiazol-3-one and n-propyl isocyanate as a white solid. mp 90-91° C.; IR(CHCl3) 3290, 1712, 1662, 1542 cm−1; 1H-NMR (CDCl3) δ1.00 (t, J=7.3 Hz, 3H), 1.52-1.72 (m, 2H), 3.39-3.44 (m, 2H), 7.42 (t, J=7.8 Hz, 1H), 7.57 (d, J=7.8 Hz, 1H), 7.70 (t, J=7.8 Hz, 1H), 8.01 (d, J=7.8 Hz, 1H), 8.89 (br s, 1H); ESIMS m/e 237 (M++1).

出典と根拠

ORDレコード
ord-84883ab8e6b14829a5a8f3f9a55fb1dd
出典データセット
uspto-grants-2009_09
特許番号
US07595403B2

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