Potassium Carbonate → HCID 57849488、化合物

HRID 737073ノート

反応式

HRID 737073 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[C:10]1([C@@H:16]2[O:21][CH2:20][CH2:19][NH:18][CH2:17]2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:18]2[CH2:19][CH2:20][O:21][C@@H:16]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:17]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 937783(2S)-2-Phenylmorpholine

生成物 1

HCID 57849488HCID 57849488、化合物収率 68%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1.417 g of 4-Bromobenzyl bromide and 0.617 g of (S)-2-Phenyl-morpholine in 11 mL of acetonitrile were stirred at room temperature and 1.567 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification by flash chromatography afforded 0.851 g of product. 68% yield ES MS m/z 331.

後処理

  1. filtrationThe solution was filtered through Celite
  2. concentrationconcentrated in vacuo
  3. customto afford a brown solid
  4. customPurification by flash chromatography

出典と根拠

ORDレコード
ord-25ee7b7d635e4fbd842faa1bbeba7652
出典データセット
uspto-grants-2009_09
特許番号
US07595397B2

反応ノート

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