Potassium Carbonate → HCID 57849481、化合物

反応式

[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.C(O)(=O)C(O)=O.[N:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH:22]2[O:27][CH2:26][CH2:25][NH:24][CH2:23]2)[CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:24]2[CH2:25][CH2:26][O:27][CH:22]([C:18]3[CH:17]=[N:16][CH:21]=[CH:20][CH:19]=3)[CH2:23]2)=[CH:4][CH:3]=1

参加物

実験手順

5.632 g of 4-Bromobenzyl bromide and 3.819 g of 2-Pyridin-3-yl morpholine oxalate (Array) in 50 mL of acetonitrile were stirred at room temperature and 6.229 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification is done by flash chromatography to afford product. Wt: 211 mg; 16% yield. ES MS m/z 334