Potassium Carbonate → HCID 57849627、化合物

HRID 737109ノート

反応式

HRID 737109 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH:10]([CH:13]1[O:18][CH2:17][CH2:16][NH:15][CH2:14]1)([CH3:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:15]2[CH2:16][CH2:17][O:18][CH:13]([CH:10]([CH3:12])[CH3:11])[CH2:14]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 198776882-(Propan-2-yl)morpholine

生成物 1

HCID 57849627HCID 57849627、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The above compound could be made in the following manner: 1.5 eq. of 4-Bromobenzyl bromide and 1 eq. of 2-Isopropyl-morpholine in acetonitrile could be stirred at room temperature and 3 eq. of potassium carbonate could be added. The reaction could be stirred at room temperature overnight. The solution could be filtered through Celite and concentrated in vacuo to afford a brown solid. Purification could be done by flash chromatography to afford product.

後処理

  1. customThe reaction
  2. filtrationThe solution could be filtered through Celite
  3. concentrationconcentrated in vacuo
  4. customto afford a brown solid
  5. customPurification
  6. customto afford product

出典と根拠

ORDレコード
ord-f76af3ff5147415eb43327fcda4bf1bd
出典データセット
uspto-grants-2009_09
特許番号
US07595397B2

反応ノート

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