4-Bromobenzyl bromide → 1-(4-Bromo-benzyl)-3-isopropyl-piperazine

HRID 737145

反応式

HRID 737145 の反応式
[CH:1]([CH:4]1[CH2:9][NH:8][CH2:7][CH2:6][NH:5]1)([CH3:3])[CH3:2].[Br:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15]Br)=[CH:13][CH:12]=1>C(#N)C>[Br:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][N:8]2[CH2:7][CH2:6][NH:5][CH:4]([CH:1]([CH3:3])[CH3:2])[CH2:9]2)=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 685274-Bromobenzyl bromideHCID 5589762-(Propan-2-yl)piperazine

生成物 1

HCID 578494561-(4-Bromo-benzyl)-3-isopropyl-piperazine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

反応条件

温度
0 °C

実験手順

0.7 g of 2-isopropyl-piperazine could be dissolved in acetonitrile and cooled to 0° C. A solution of 0.5 quiv. 4-bromobenzylbromide in acetonitrile could be added dropwise over 1 h. The reaction would be stirred at room temperature for 2 h. The reaction mixture could be concentrated and the residue could be purified by column chromatography (silica, eluent dichloromethane, 0-5% methanol, 0-0.5% dimethylethylamine) to afford 1-(4-bromo-benzyl)-3-isopropyl-piperazine.

後処理

  1. customThe reaction
  2. concentrationThe reaction mixture could be concentrated
  3. customthe residue could be purified by column chromatography (silica, eluent dichloromethane, 0-5% methanol, 0-0.5% dimethylethylamine)

出典と根拠

ORDレコード
ord-ab84154b14f74b55ad5a7dce6f1af402
出典データセット
uspto-grants-2009_09
特許番号
US07595397B2

関連ノート

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