(S)-2-[4-(4-Cyclopropylcarbamoyl-phenyl)-thiazol-2-ylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester → (S)-Thiazolidine-2-carboxylic acid [4-(4-cyclopropylcarbamoyl-phenyl)-thiazol-2-yl]-amide

HRID 737185ノート

反応式

HRID 737185 の反応式
C(OC([N:8]1[CH2:12][CH2:11][S:10][C@H:9]1[C:13](=[O:32])[NH:14][C:15]1[S:16][CH:17]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:31])[NH:27][CH:28]3[CH2:30][CH2:29]3)=[CH:22][CH:21]=2)[N:19]=1)=O)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[CH:28]1([NH:27][C:26]([C:23]2[CH:22]=[CH:21][C:20]([C:18]3[N:19]=[C:15]([NH:14][C:13]([C@H:9]4[NH:8][CH2:12][CH2:11][S:10]4)=[O:32])[S:16][CH:17]=3)=[CH:25][CH:24]=2)=[O:31])[CH2:30][CH2:29]1

参加物

4

反応物 1

HCID 57849787(S)-2-[4-(4-Cyclopropylcarbamoyl-phenyl)-thiazol-2-ylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester

生成物 1

HCID 86616434(S)-Thiazolidine-2-carboxylic acid [4-(4-cyclopropylcarbamoyl-phenyl)-thiazol-2-yl]-amide

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of (S)-2-[4-(4-cyclopropylcarbamoyl-phenyl)-thiazol-2-ylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester (341.6 mg, 0.72 mmol) in dichloromethane (3 mL) and trifluoroacetic acid (3 mL) was stirred at ambient temperature overnight. The reaction was filtered and purified by reverse phase HPLC to give the desired product.

後処理

  1. filtrationThe reaction was filtered
  2. custompurified by reverse phase HPLC

出典と根拠

ORDレコード
ord-4c5de14eb8514bbfb6e839cc74ede4a5
出典データセット
uspto-grants-2009_09
特許番号
US07595398B2

反応ノート

読み込み中…