5-Bromo-6-chloropyridine-3-carboxylic acid → 5-bromo-6-chloro-N-(4-((chlorodifluoromethyl)thio)phenyl)nicotinamide

HRID 73775

反応式

HRID 73775 の反応式
[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[Cl:12][C:13]([F:23])([F:22])[S:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:19][C:18]1[CH:20]=[CH:21][C:15]([S:14][C:13]([Cl:12])([F:22])[F:23])=[CH:16][CH:17]=1)=[O:9]

参加物

3

反応物 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 56624957HCID 56624957、化合物

生成物 1

HCID 867026185-bromo-6-chloro-N-(4-((chlorodifluoromethyl)thio)phenyl)nicotinamide

実験手順

The title compound was prepared in an analogous fashion to that described in Stage 11.2 using 5-bromo-6-chloro-nicotinic acid and 4-((chloro-difluoromethyl)thio)aniline (Stage 18.3) to afford an off-white crystalline solid. HPLC (Condition 4) tR=6.78 min, UPLC-MS (Condition 3) tR=1.32 min, m/z=425 [M−H]−.

後処理

  1. customto afford an off-white crystalline solid

出典と根拠

ORDレコード
ord-2e20c9ebd32648309d5f92851d6f7241
出典データセット
uspto-grants-2014_09
特許番号
US08829195B2

関連ノート

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