p-Toluidine → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

反応式

Cc1ccc(N)cc1.FC(F)(F)c1ccc(Br)cc1>CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.COc1ccc(OC)c([P](C23CC4CC(CC(C4)C2)C3)(C23CC4CC(CC(C4)C2)C3)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O>Cc1ccc(Nc2ccc(C(F)(F)F)cc2)cc1

参加物

反応条件

温度: 60 °C

実験手順

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

後処理

addition手順は記録されていません

出典と根拠

ORDレコード: ord-390cf0515dda4660a784fda88a0fed4f
出典データセット: Ahneman
DOI: 10.1126/science.aar5169

反応ノート

読み込み中…

参加物

反応物 2

HCID 7813p-Toluidine

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

生成物 1

HCID 187127994-methyl-N-(4-(trifluoromethyl)phenyl)aniline収率 35.45%

試薬・触媒・溶媒 3

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramine試薬

HCID 178492609HCID 178492609、化合物触媒

HCID 679Dimethyl Sulfoxide溶媒5 回

反応条件

温度: 60 °C

実験手順

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

後処理

addition手順は記録されていません

出典と根拠

ORDレコード: ord-390cf0515dda4660a784fda88a0fed4f
出典データセット: Ahneman
DOI: 10.1126/science.aar5169

反応ノート

読み込み中…