反応式
[Cl:1][C:2]1[C:10]([I:11])=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[Cl:12][C:13]([F:23])([F:22])[O:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Cl:1][C:2]1[C:10]([I:11])=[CH:9][C:5]([C:6]([NH:19][C:18]2[CH:20]=[CH:21][C:15]([O:14][C:13]([Cl:12])([F:22])[F:23])=[CH:16][CH:17]=2)=[O:8])=[CH:4][N:3]=1参加物
3
実験手順
The title compound was prepared in an analogous fashion to that described in Stage 11.2 using 6-chloro-5-iodonicotinic acid and 4-(chlorodifluoromethoxy)aniline to afford an off-white powder. HPLC (Condition 4) tR=6.47 min, UPLC-MS (Condition 3) tR=1.26 min, m/z=456.8 [M−H]−.
後処理
- customto afford an off-white powder
出典と根拠
- ORDレコード
- ord-f324f55a49224e8a8e5a5fed04932a04
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08829195B2
関連ノート
読み込み中…