3-Methyl-2-thenoyl Chloride → 1-[[(3-Methyl-2-thienyl)carbonyl]amino]cyclohexanecarboxylic acid methyl ester

HRID 73824

反応式

HRID 73824 の反応式
Cl.[CH3:2][O:3][C:4]([C:6]1([NH2:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5].[CH3:13][C:14]1[CH:18]=[CH:17][S:16][C:15]=1[C:19](Cl)=[O:20]>>[CH3:2][O:3][C:4]([C:6]1([NH:12][C:19]([C:15]2[S:16][CH:17]=[CH:18][C:14]=2[CH3:13])=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:5]

参加物

3

反応物 2

HCID 27376053-Methyl-2-thenoyl ChlorideHCID 22645079Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

生成物 1

HCID 324685211-[[(3-Methyl-2-thienyl)carbonyl]amino]cyclohexanecarboxylic acid methyl ester収率 47%

実験手順

581 mg (3 mmol) of 1-aminocyclohexanecarboxylic acid methyl ester hydrochloride was used instead of 1-aminocyclohexanecarboxylic acid phenylmethyl ester, and 482 mg (3 mmol) of 3-methyl-2-thiophenecarbonyl chloride was used instead of phenylacetyl chloride in the process according to Reference Example 1 to obtain 394 mg (47%) of the title compound.

出典と根拠

ORDレコード
ord-115d9aa10ec54874a1d6b746c5951c72
出典データセット
uspto-grants-2014_09
特許番号
US08829209B2

関連ノート

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