O-Toluidine → 2,2,2'-Trimethylpropionanilide

HRID 73917

反応式

HRID 73917 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:7]=1[NH2:8].CCN(CC)CC.[CH3:16][C:17]([CH3:22])([CH3:21])[C:18](Cl)=[O:19]>C(Cl)Cl>[CH3:16][C:17]([CH3:22])([CH3:21])[C:18]([NH:8][C:7]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:1])=[O:19]

参加物

5

反応物 3

HCID 7242O-ToluidineHCID 8471TriethylamineHCID 62493Pivaloyl chloride

生成物 1

HCID 27340052,2,2'-Trimethylpropionanilide収率 92%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of o-tolylamine (21.4 g, 0.20 mol) and Et3N (22.3 g, 0.22 mol) in CH2Cl2 was added 2,2-dimethyl-propionyl chloride (25.3 g, 0.21 mol) at 10° C. The mixture was stirred overnight at room temperature, washed with aq. HCl (5%, 80 mL), saturated NaHCO3 solution and brine, dried over Na2SO4 and concentrated under vacuum to give 2,2-dimethyl-N-o-tolyl-propionamide (35.0 g, 92%).

後処理

  1. washwashed with aq. HCl (5%, 80 mL), saturated NaHCO3 solution and brine
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-26bfae6312334bdeb91abea16eba4fa8
出典データセット
uspto-grants-2014_09
特許番号
US08829204B2

関連ノート

読み込み中…