4-Bromoanisole → 4-Methoxy-4'-methyldiphenylamine

反応式

COc1ccc(Br)cc1.Cc1ccc(N)cc1>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c(C(C)C)c1.CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CS(C)=O.Fc1cccc(F)c1-c1ccno1>COc1ccc(Nc2ccc(C)cc2)cc1

参加物

反応条件

温度: 60 °C

実験手順

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

後処理

addition手順は記録されていません

出典と根拠

ORDレコード: ord-0dcbfd688f184a41b80af51f2921b827
出典データセット: Ahneman
DOI: 10.1126/science.aar5169

反応ノート

読み込み中…

参加物

反応物 2

HCID 77304-Bromoanisole

HCID 7813p-Toluidine

生成物 1

HCID 114358284-Methoxy-4'-methyldiphenylamine収率 8.641%

試薬・触媒・溶媒 4

HCID 27747145-(2,6-Difluorophenyl)isoxazole試薬

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramine試薬

HCID 178439018HCID 178439018、化合物触媒

HCID 679Dimethyl Sulfoxide溶媒5 回

反応条件

温度: 60 °C

実験手順

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

後処理

addition手順は記録されていません

出典と根拠

ORDレコード: ord-0dcbfd688f184a41b80af51f2921b827
出典データセット: Ahneman
DOI: 10.1126/science.aar5169

反応ノート

読み込み中…