Indoline → HCID 178418799、化合物

HRID 7414

反応式

HRID 7414 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.CS[C:12]1[N:17]=[C:16]([OH:18])[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][N:13]=1>C(O)C>[OH:18][C:16]1[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][N:13]=[C:12]([N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH2:3][CH2:2]2)[N:17]=1

参加物

4

反応物 2

HCID 10328IndolineHCID 178418871HCID 178418871、化合物

生成物 1

HCID 178418799HCID 178418799、化合物収率 77.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of indoline (3.58 g, 30 mmol) in ethanol (50 mL) was added ethyl 2-methylthio-4-hydroxypyrimidine-5-carboxylate (5.35 g, 25 mmol) and the mixture was heated under reflux for 18 h. The reaction mixture was allowed to cool to room temperature and the precipitated crystals were collected by filtration. The crystals were washed several times with cold ethanol and dried to give the title compound (5.5 g, 77%) as crystals.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 18 h
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe crystals were washed several times with cold ethanol
  5. customdried

出典と根拠

ORDレコード
ord-b3ebf651e99d40be9d11ee0c8e9016bb
出典データセット
uspto-grants-2006_08
特許番号
US07087597B1

関連ノート

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