(3-Aminopyrazin-2-yl)methanol → 3-Aminopyrazine-2-carbaldehyde
反応式
[NH2:1][C:2]1[C:3]([CH2:8][OH:9])=[N:4][CH:5]=[CH:6][N:7]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[C:3]([CH:8]=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1参加物
4
実験手順
A suspension of 3-aminopyrazine methanol, 6.3 g (0.05 mol) and manganese dioxide (38.0 g) in 400 mL of chloroform is stirred at room temperature for two hours and the resulting solid is filtered off. The filtrate is evaporated to dryness which gives the desired product as a yellow crystalline solid, (5.00 g, 82% yield) having a melting point 110°-114° C.
後処理
- filtrationthe resulting solid is filtered off
- customThe filtrate is evaporated to dryness which
出典と根拠
- ORDレコード
- ord-39e47edfd5e8453a98c5fdf784db6535
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05554579
反応ノート
読み込み中…