Triethylamine → 3-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one

HRID 742228

反応式

HRID 742228 の反応式
[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([N:8]=[C:9]=[S:10])[CH:5]=[CH:6][CH:7]=1.Cl.C([O:15][C:16](=O)[CH2:17][NH:18][CH3:19])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:3]([CH3:11])=[C:4]([N:8]2[C:16](=[O:15])[CH2:17][N:18]([CH3:19])[C:9]2=[S:10])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1405041-Chloro-3-isothiocyanato-2-methylbenzeneHCID 171173Ethyl N-methylaminoacetate hydrochloride

生成物 1

HCID 189682123-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one収率 83.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The title compound was prepared by the procedure described in Example 1 using 13.2 g of 3-chloro-2-methylphenyl-isothiocyanate, 11.0 g of sarcosine ethyl ester hydrochloride, 25 g of triethyl amine, and 300 mL of chloroform. Crystallization from diethyl ether afforded the title compound (15.2 g) as a tan solid, m.p. 122°-124° C. Anal. Calcd. for C11H11Cl N2O S: C, 51.87; H, 4.35; N,11.00. Found: C, 51.96; H, 4.21; N, 11.05. Mass spectrum (EI, M.+) m/z 254/256.

後処理

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from diethyl ether

出典と根拠

ORDレコード
ord-e1176e7dc4fa4fa3bf374c0dee41fffa
出典データセット
uspto-grants-1996_09
特許番号
US05554607

関連ノート

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