Triethylamine → 3-(2-Chloro-4-methylphenyl)-1-ethyl-2-thioxo-imidazolidin-4-one

HRID 742255

反応式

HRID 742255 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[CH2:12]([NH:14][CH2:15][C:16](O)=[O:17])[CH3:13].C(N(CC)CC)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:16](=[O:17])[CH2:15][N:14]([CH2:12][CH3:13])[C:10]1=[S:11]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1435292-Chloro-4-methylphenyl isothiocyanateHCID 316542N-Ethylglycine

生成物 1

HCID 194253743-(2-Chloro-4-methylphenyl)-1-ethyl-2-thioxo-imidazolidin-4-one収率 21.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The title compound was prepared by the procedure described in Example 28 using 18.3 g of 2-chloro-4-methylphenyl-isothiocyanate, 18.4 g of N-ethyl glycine, 20.2 g of triethyl amine, and 300 mL of chloroform. Crystallization from ethyl acetate afforded the title compound (5.8 g) as a peach solid, m.p. 126°-128° C. Anal. Calcd. for. C12H13Cl N2O S: C, 53.63; H, 4.88; N, 10.42. Found: C, 53.50; H, 4.76; N, 10.28. Mass spectrum (+FAB, IM+H]+) m/z 269/271.

後処理

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-94fab187c7ba44d2a6cc0365d8243fc1
出典データセット
uspto-grants-1996_09
特許番号
US05554607

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