Hydrochloric Acid → (4-Methylphenyl)(pyridin-2-yl)methanone

HRID 742327ノート

反応式

HRID 742327 の反応式
[Mg].II.Br[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1.[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)#N.Cl.CC[O:23]CC>O1CCCC1>[CH3:11][C:8]1[CH:9]=[CH:10][C:5]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[O:23])=[CH:6][CH:7]=1

参加物

8

反応物 6

HCID 313Hydrochloric AcidHCID 807IodineHCID 3283Diethyl Ether2 回HCID 7522Pyridine-2-carbonitrileHCID 78054-BromotolueneHCID 5462224Magnesium

生成物 1

HCID 3018781(4-Methylphenyl)(pyridin-2-yl)methanone収率 62%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In a 250 mL flask were placed 1.425 g (58.5 mmol) of magnesium turnings, 35 mL of anhydrous ether and a iodine crystal. Next, 10 g (58.8 mmol) of 4-bromotoluene dissolved in 70 mL of ether was added dropwise. After the addition was complete, the resulting mixture was heated at reflux for 30 min. Then a solution of 6 g (58.5 mmol) of 2-cyanopyridine in 35 mL of anhydrous tetrahydrofuran was added dropwise and the reaction mixture was stirred at room temperature overnight. The resulting mixture was poured into 1N HCl and extracted several times with ethyl acetate. The organic phase was dried and the solvent was removed, to afford a crude product that was chromatographed on silica gel (hexane-ethyl acetate mixtures of increasing polarity) to give 7.2 g of the desired product (yield: 62%).

後処理

  1. customIn a 250 mL flask were placed
  2. additionwas added dropwise
  3. additionAfter the addition
  4. temperaturethe resulting mixture was heated
  5. temperatureat reflux for 30 min
  6. extractionextracted several times with ethyl acetate
  7. customThe organic phase was dried
  8. customthe solvent was removed
  9. customto afford a crude product that
  10. customwas chromatographed on silica gel (hexane-ethyl acetate mixtures of increasing polarity)

出典と根拠

ORDレコード
ord-905c37e2c7b5496d805702e798686598
出典データセット
uspto-grants-1996_09
特許番号
US05554624

反応ノート

読み込み中…