N-Acetyl-4-aminobiphenyl → Acetamide, N-(3-nitro(1,1'-biphenyl)-4-yl)-

HRID 742367

反応式

HRID 742367 の反応式
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3].[N+:17]([O-])([O-:19])=[O:18].[K+]>C(O)(=O)C.S(=O)(=O)(O)O>[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][C:6]=1[N+:17]([O-:19])=[O:18])[C:2]([CH3:4])=[O:3]

参加物

5

反応物 2

HCID 19998N-Acetyl-4-aminobiphenylHCID 24434Potassium Nitrate

生成物 1

HCID 79364Acetamide, N-(3-nitro(1,1'-biphenyl)-4-yl)-収率 42.1%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 1118Sulfuric Acid溶媒

実験手順

4-Acetaminobiphenyl (17 g, 80.57 mmol)in glacial acetic acid (600 ml) was added a solution of potassium nitrate (18 g, 178 mmol) in conc. sulphuric acid (75 ml) at such a rate that the temperature was kept below 30° C. Following the addition the mixture was stirred at ambient temperature for 72 hours. The reaction mixture was poured into ice-water (1200 ml). The product was filtered off, washed thoroughly with water and dried. Recrystallization from EtOH (99%, 150 ml) afforded 4-acetamino-3-nitrobiphenyl (8.7 g).

後処理

  1. customwas kept below 30° C
  2. additionthe addition the mixture
  3. filtrationThe product was filtered off
  4. washwashed thoroughly with water
  5. customdried
  6. customRecrystallization from EtOH (99%, 150 ml)

出典と根拠

ORDレコード
ord-decad50747bd47d5a9f84058d6b1036f
出典データセット
uspto-grants-1996_09
特許番号
US05554632

関連ノート

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