3-Isopropoxybenzaldehyde → (3-Isopropoxyphenyl)methanol
反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9])([CH3:3])[CH3:2].[BH4-].[Na+]>C(O)C>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][OH:9])([CH3:3])[CH3:2]参加物
4
実験手順
To m-isopropoxybenzaldehyde (38 g, 0.23 mol) in 500 mL of ethanol was added slowly sodium borohydride (12.2 g, 0.32 mol) over a period of 1 h and the mixture was stirred for 2 h, filtered, and concentrated to 100 mL of its volume. The above mixture was diluted with 50 mL of water, neutralized with sulfuric acid solution with cooling, and was extracted with ether (4×100 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to afford 36.32 g (95%) of m-isopropoxybenzyl alcohol.
後処理
- filtrationfiltered
- concentrationconcentrated to 100 mL of its volume
- additionThe above mixture was diluted with 50 mL of water
- temperaturewith cooling
- extractionwas extracted with ether (4×100 mL)
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-7f43f692ea4849dd80d644de78b6860a
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05554620
反応ノート
読み込み中…