3-Isopropoxybenzaldehyde → (3-Isopropoxyphenyl)methanol

HRID 742458

反応式

HRID 742458 の反応式
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9])([CH3:3])[CH3:2].[BH4-].[Na+]>C(O)C>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][OH:9])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 7129143-IsopropoxybenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 2759474(3-Isopropoxyphenyl)methanol収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To m-isopropoxybenzaldehyde (38 g, 0.23 mol) in 500 mL of ethanol was added slowly sodium borohydride (12.2 g, 0.32 mol) over a period of 1 h and the mixture was stirred for 2 h, filtered, and concentrated to 100 mL of its volume. The above mixture was diluted with 50 mL of water, neutralized with sulfuric acid solution with cooling, and was extracted with ether (4×100 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to afford 36.32 g (95%) of m-isopropoxybenzyl alcohol.

後処理

  1. filtrationfiltered
  2. concentrationconcentrated to 100 mL of its volume
  3. additionThe above mixture was diluted with 50 mL of water
  4. temperaturewith cooling
  5. extractionwas extracted with ether (4×100 mL)
  6. dry with materialThe organic layer was dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-7f43f692ea4849dd80d644de78b6860a
出典データセット
uspto-grants-1996_09
特許番号
US05554620

関連ノート

読み込み中…