Hydrochloric Acid → (3-Chloro-4-methoxyphenyl)methanol

HRID 7425ノート

反応式

HRID 7425 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:5](OC)=[O:6].[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH2:5][OH:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 123469Methyl 3-chloro-p-anisateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 4312004(3-Chloro-4-methoxyphenyl)methanol収率 106.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl 3-chloro-4-methoxybenzoate (1.2 g, 6 mmol) in tetrahydrofuran (10 ml) was added under ice-cooling lithium aluminum hydride (455 mg, 12 mmol) and the mixture was stirred at room temperature for 1 h. The reaction mixture was stirred under ice-cooling and 0.1N hydrochloric acid was added. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.1 g, 100%).

後処理

  1. stirringThe reaction mixture was stirred under ice-
  2. temperaturecooling
  3. extractionThe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-2bf43f8c975c483f9da765c710675886
出典データセット
uspto-grants-2006_08
特許番号
US07087597B1

反応ノート

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