Water → 4-Cyanophenyl 4-[(prop-2-en-1-yl)oxy]benzoate

HRID 742522ノート

反応式

HRID 742522 の反応式
[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)[CH:2]=[CH2:3].[C:14]([C:16]1[CH:21]=[CH:20][C:19](O)=[CH:18][CH:17]=1)#[N:15].O>C(Cl)(Cl)Cl>[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([O:11][C:19]2[CH:20]=[CH:21][C:16]([C:14]#[N:15])=[CH:17][CH:18]=2)=[O:10])=[CH:7][CH:6]=1)[CH:2]=[CH2:3]

参加物

5

反応物 3

HCID 962WaterHCID 130194-CyanophenolHCID 4606904-(Prop-2-en-1-yloxy)benzoic acid

生成物 1

HCID 149851184-Cyanophenyl 4-[(prop-2-en-1-yl)oxy]benzoate収率 77.1%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

15.0 g of PPE, 4.00 g (22.4 mmol) of the compound (12) and 2.66 g (22.3 mmol) of p-cyanophenol were dissolved in ml of chloroform under an argon gas atmosphere and the whole was stirred at room temperature overnight. After addition of water to the reaction mixture, the whole was extracted with methylene chloride. After removal of the solvent by distillation, the residue was purified by silica gel column chromatography to obtain 4.80 g of p-cyanophenyl p-allyloxybenzoate (17) as a white solid (yield: 76.7%).

後処理

  1. extractionthe whole was extracted with methylene chloride
  2. customAfter removal of the solvent
  3. distillationby distillation
  4. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-619c789cc3b64082989a30e7db5218b9
出典データセット
uspto-grants-1996_09
特許番号
US05554706

反応ノート

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