Water → 2-(4-Isoproylamino-3-nitrophenyl)benzoxazole

HRID 74253ノート

反応式

HRID 74253 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].C(=O)([O-])[O-].[K+].[K+].[CH:26]([NH2:29])([CH3:28])[CH3:27].O>C(O)C>[CH:26]([NH:29][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18])([CH3:28])[CH3:27]

参加物

6

反応物 4

HCID 962WaterHCID 6363IsopropylamineHCID 11430Potassium CarbonateHCID 219909702-(4-Fluoro-3-nitrophenyl)benzoxazole

生成物 1

HCID 674980622-(4-Isoproylamino-3-nitrophenyl)benzoxazole収率 99%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 2-(4-fluoro-3-nitrophenyl)benzoxazole (see Working Example 15-2) (200 mg, 0.774 mmol) in ethanol (5 mL) was added potassium carbonate (214 mg, 1.55 mmol) and isopropylamine (137 mg, 2.32 mmol), and this was heated to reflux for 4 hours. After the reaction was complete, this was cooled to room temperature, water was added, and after the precipitated crystals were filtered and washed with water, they were dried to yield the title compound (227 mg, 99% yield).

後処理

  1. temperaturethis was heated
  2. temperatureto reflux for 4 hours
  3. filtrationafter the precipitated crystals were filtered
  4. washwashed with water, they
  5. customwere dried

出典と根拠

ORDレコード
ord-a2f6c3f195c14ad9a52e22956408c4a6
出典データセット
uspto-grants-2014_09
特許番号
US08829035B2

反応ノート

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