2-(4-Isoproylamino-3-nitrophenyl)benzoxazole → 2-(2-Isopropylaminoanilin-5-yl)benzoxazole

HRID 74254ノート

反応式

HRID 74254 の反応式
[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=3[N:15]=2)=[CH:7][C:6]=1[N+:20]([O-])=O)([CH3:3])[CH3:2].[H][H]>[C].[Pd].O1CCCC1>[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=3[N:15]=2)=[CH:7][C:6]=1[NH2:20])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 674980622-(4-Isoproylamino-3-nitrophenyl)benzoxazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 674987282-(2-Isopropylaminoanilin-5-yl)benzoxazole収率 91.4%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a tetrahydrofuran solution (5 mL) of 2-(4-isopropylamino-3-nitrophenyl)benzoxazole (see Working Example 80-1) (224 mg, 0.753 mmol) was added 10% palladium-carbon (40 mg), a hydrogen atmosphere was substituted in the flask, and this was stirred at room temperature for 15 hours. After the reaction was complete, this was filtered through Celite and the filtrate was concentrated. The residue obtained was purified by silica gel column chromatography to yield the title compound (184 mg, 91% yield).

後処理

  1. filtrationthis was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue obtained
  4. customwas purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-c8e3833fc24a433e9f5c15781aa1edf9
出典データセット
uspto-grants-2014_09
特許番号
US08829035B2

反応ノート

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