2-(4-Neopentylamino-3-nitrophenyl)benzoxazole → 2-(2-Neopentylaminoanilin-5-yl)benzoxazole

HRID 74257

反応式

HRID 74257 の反応式
[CH2:1]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[O:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)=[CH:9][C:8]=1[N+:22]([O-])=O)[C:2]([CH3:5])([CH3:4])[CH3:3].[H][H]>[C].[Pd].O1CCCC1>[CH2:1]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[O:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)=[CH:9][C:8]=1[NH2:22])[C:2]([CH3:5])([CH3:4])[CH3:3]

参加物

5

反応物 2

HCID 674990142-(4-Neopentylamino-3-nitrophenyl)benzoxazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 674978662-(2-Neopentylaminoanilin-5-yl)benzoxazole収率 89.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a tetrahydrofuran solution (5 mL) of 2-(4-neopentylamino-3-nitrophenyl)benzoxazole (see Working Example 81-1) (242 mg, 0.744 mmol) was added 10% palladium-carbon (40 mg), a hydrogen atmosphere was substituted in the flask, and this was stirred at room temperature for 15 hours. After the reaction was complete, this was filtered through Celite and the filtrate was concentrated. The residue obtained was purified by silica gel column chromatography to yield the title compound (196 mg, 89% yield).

後処理

  1. filtrationthis was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue obtained
  4. customwas purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-11f03d1e0fb8423a8aaa20d19de03e28
出典データセット
uspto-grants-2014_09
特許番号
US08829035B2

関連ノート

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