Tetrahydrofuran → 2-(2-(3-(Morpholin-4-yl)-n-propyl)aminoanilin-4-yl)benzoxazole

HRID 74279ノート

反応式

HRID 74279 の反応式
N1(C(C)C[NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[O:17][C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[N:20]=3)=[CH:12][C:11]=2[N+:25]([O-])=O)CCOCC1.[H][H].[O:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>[C].[Pd]>[N:9]1([CH2:10][CH2:11][CH2:12][NH:25][C:11]2[CH:12]=[C:13]([C:16]3[O:17][C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[N:20]=3)[CH:14]=[CH:15][C:10]=2[NH2:9])[CH2:34][CH2:35][O:31][CH2:32][CH2:33]1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 674985632-(N-(2-(morpholin-4-yl)-n-propyl)-2-nitroanilin-4-yl)benzoxazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 674982532-(2-(3-(Morpholin-4-yl)-n-propyl)aminoanilin-4-yl)benzoxazole収率 99%

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

To a solution of 2-(N-(2-(morpholin-4-yl)-n-propyl)-2-nitroanilin-4-yl)benzoxazole (see Working Example 96-1) (665 mg, 1.74 mmol) in tetrahydrofuran (10 mL) was added 10% palladium-carbon (70 mg). A hydrogen atmosphere was then substituted in the flask, and this was stirred at room temperature for 17 hours. After the reaction was finished, this was filtered through Celite, and the filtrate was concentrated to yield the title compound (605 mg, 99% yield).

後処理

  1. filtrationthis was filtered through Celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-29eb486814c94c0e888b39ee379cfbf7
出典データセット
uspto-grants-2014_09
特許番号
US08829035B2

反応ノート

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