Sodium Iodide → N-butyl-5-iodo-N-methyl-pentanesulfonamide
反応式
[I-:1].[Na+].[CH2:3]([N:7]([CH3:17])[S:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]Cl)(=[O:10])=[O:9])[CH2:4][CH2:5][CH3:6]>C(C(C)=O)C>[CH2:3]([N:7]([CH3:17])[S:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][I:1])(=[O:10])=[O:9])[CH2:4][CH2:5][CH3:6]参加物
4
実験手順
526 mg of sodium iodide were added to a solution of 449 mg of the product of Step A in 4.5 ml of methyl ethyl ketone, and the mixture was stirred at reflux for 4 hours. After cooling, the methyl ethyl ketone was evaporated under reduced pressure and water was added. Extraction was carried out with ethyl acetate and the extracts were washed with water, then with a saturated aqueous solution of sodium chloride, dried and evaporated to dryness under reduced pressure to obtain 572 mg of the expected product.
後処理
- temperatureat reflux for 4 hours
- temperatureAfter cooling
- customthe methyl ethyl ketone was evaporated under reduced pressure and water
- additionwas added
- extractionExtraction
- washthe extracts were washed with water
- dry with materialwith a saturated aqueous solution of sodium chloride, dried
- customevaporated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-23d789ad91c24812bc180d0a32b101da
- 出典データセット
- uspto-grants-1996_09
- 特許番号
- US05556845
反応ノート
読み込み中…