Epibromohydrin → 2-{2-[4-(2-Methoxyphenyl)butyl]phenoxymethyl}oxirane

HRID 743196

反応式

HRID 743196 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19].[CH3:20][C:21](C)([O-:23])[CH3:22].[K+].C(C1OC1)Br>CC(N(C)C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH2:20][CH:21]1[CH2:22][O:23]1

参加物

5

反応物 3

HCID 18430EpibromohydrinHCID 194239792-[4-(2-Methoxyphenyl)butyl]phenolHCID 23665647Potassium tert-butoxide

生成物 1

HCID 106388632-{2-[4-(2-Methoxyphenyl)butyl]phenoxymethyl}oxirane収率 93%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

Following a procedure similar to that described in Example 1(a), 230 mg of 2-[4-(2-methoxyphenyl)butyl]phenol (prepared as described in Preparation 4), 101 mg of potassium t-butoxide and 246 mg of epibromohydrin were reacted in 15 ml of dimethylacetamide. The crude product, extracted as described in Example 1(a), was purified as described in Example 1(a), to give 260 mg (yield 93%) of the title compound as an oil.

後処理

  1. extractionThe crude product, extracted
  2. customwas purified

出典と根拠

ORDレコード
ord-26eb422a15f1495bbb522969fe987898
出典データセット
uspto-grants-1996_09
特許番号
US05556864

関連ノート

読み込み中…