Imidazole → 3-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol

HRID 743206ノート

反応式

HRID 743206 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[C:6]1([CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=2[O:18][CH2:19][CH:20]2[CH2:22][O:21]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(#N)C>[N:1]1([CH2:22][CH:20]([OH:21])[CH2:19][O:18][C:17]2[CH:23]=[CH:24][CH:25]=[CH:26][C:16]=2[CH2:15][CH2:14][CH2:13][CH2:12][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 2

HCID 795ImidazoleHCID 104931782-[2-(4-Phenylbutyl)phenoxymethyl]oxirane

生成物 1

HCID 194239523-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol収率 82.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

940 mg of imidazole were added to a solution of 780 mg of 2-[2-(4-phenylbutyl)phenoxymethyl]oxirane [prepared as described in Example 1(a)] in 25 ml of acetonitrile, and the resulting mixture was heated under reflux for 24 hours. At the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 20:1 by volume mixture of methylene chloride and methanol as the eluent, to give 798 mg (yield 82%) of the title compound as a pale yellow oil.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 24 hours
  3. distillationAt the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure
  4. customThe resulting residue was purified by column chromatography through silica gel
  5. additionby volume mixture of methylene chloride and methanol as the eluent

出典と根拠

ORDレコード
ord-8f9b8976c0804d67855e7f0e00a7aedc
出典データセット
uspto-grants-1996_09
特許番号
US05556864

反応ノート

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