Epibromohydrin → 2-{2-[4-(2-Benzyloxyphenyl)-1-buten-1-yl]phenoxymethyl}oxirane

反応式

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH:17]=[CH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[OH:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:26][C:27](C)([O-:29])[CH3:28].[K+].C(C1OC1)Br>CC(N(C)C)=O>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH:17]=[CH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH2:26][CH:27]1[CH2:28][O:29]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

実験手順

Following a procedure similar to that described in Example 1(a), 330 mg of 2-[4-(2-benzyloxyphenyl)-1-buten-1-yl)phenol (prepared as described in Preparation 14), 124 mg of potassium t-butoxide and 151 mg of epibromohydrin were reacted in 10 ml of dimethylacetamide. The crude product, extracted as described in Example 1(a), was purified as described in Example 1(a), to give 328 mg (yield 85%) of the title compound as a colorless oil.