1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-(2-Benzyloxyphenyl)-4-(3-chlorophenyl)butadiene

HRID 743399ノート

反応式

HRID 743399 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=O)[CH:5]=[CH:6][CH:7]=1.[Cl-].[CH2:13]([O:20][C:21]1[CH:46]=[CH:45][CH:44]=[CH:43][C:22]=1[CH2:23][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.N12CCCN=C1CCCCC2>C(#N)C>[CH2:13]([O:20][C:21]1[CH:46]=[CH:45][CH:44]=[CH:43][C:22]=1[CH:23]=[CH:10][CH:9]=[CH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

5

反応物 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 27631113-(3-Chlorophenyl)prop-2-enalHCID 194239672-Benzyloxybenzyltriphenylphosphonium chloride

生成物 1

HCID 545226781-(2-Benzyloxyphenyl)-4-(3-chlorophenyl)butadiene収率 94%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Following a procedure similar to that described in the first part of Preparation 3, the whole of this 3-(3-chlorophenyl)-2-propenal was reacted with 6.9 g of 2-benzyloxybenzyltriphenylphosphonium chloride (prepared as described in Preparation 1) and 2.89 g of 1,8-diazabicyclo[5,4,0]undec-7-ene in 100 ml of acetonitrile. The crude product, extracted as described in the first part of Preparation 3, was purified as described in the first part of Preparation 3, to give 4.13 g (yield 94%) of 1-(2-benzyloxyphenyl)-4-(3-chlorophenyl)butadiene as an oil.

後処理

  1. customthat described in the first part of Preparation 3
  2. extractionThe crude product, extracted
  3. customas described in the first part of Preparation 3
  4. customwas purified
  5. customas described in the first part of Preparation 3

出典と根拠

ORDレコード
ord-9d499ca1328845e99ea443d258b77e96
出典データセット
uspto-grants-1996_09
特許番号
US05556864

反応ノート

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