2-Chlorobenzaldehyde → 2-Chlorocinnamaldehyde

HRID 743402

反応式

HRID 743402 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.C1(P(=[CH:29][CH:30]=[O:31])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(#N)C>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[CH:29][CH:30]=[O:31]

参加物

4

反応物 2

HCID 69962-ChlorobenzaldehydeHCID 75051(Triphenylphosphoranylidene)acetaldehyde

生成物 1

HCID 30140422-Chlorocinnamaldehyde収率 68.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Following a procedure similar to that described in the first part of Preparation 17, 3.00 g of 2-chlorobenzaldehyde and 7.5 g of (triphenylphosphoranylidene)acetaldehyde were reacted in 100 ml of acetonitrile. The crude product thus obtained was purified by column chromatography through silica gel, using a 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.44 g (yield 68%) of 3-(2-chlorophenyl)-2-propenal as a solid.

後処理

  1. customThe crude product thus obtained
  2. customwas purified by column chromatography through silica gel
  3. additionby volume mixture of hexane and ethyl acetate as the eluent

出典と根拠

ORDレコード
ord-3ec02909709d487c874bb027c60589aa
出典データセット
uspto-grants-1996_09
特許番号
US05556864

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