Ammonia → 4-(4-(4-Pyridyl)piperazin-1-yl)phenol

HRID 743812

反応式

HRID 743812 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.O.N>Br>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 962WaterHCID 149869024-[4-(4-Pyridyl)piperazin-1-yl]anisole

生成物 1

HCID 149869034-(4-(4-Pyridyl)piperazin-1-yl)phenol収率 95.6%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

実験手順

The product from step (i) (1.5 g) in concentrated hydrobromic acid (30 ml) was heated under argon at 130°-135° C. for 21/2 hours. The solution was cooled, poured into water (150 ml) and basified with aqueous ammonia. The precipitate was filtered, washed with water and dried to give 4-[4(4-pyridyl)piperazin-1-yl]phenol (1.36 g) as a solid: m.p. 310°-312° C.; NMR(d6DMSO) δ8.2(2H,d); 6.8(4H,m); 6.66(2H,d); 3.45(4H,m); 3.08(4H,m).

後処理

  1. temperatureThe solution was cooled
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-320e5af793114cc5818a746149456eb3
出典データセット
uspto-grants-1996_09
特許番号
US05556977

関連ノート

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