Nitric Acid → 2-(3-Methyl-4-nitrophenyl)benzonitrile

HRID 743893

反応式

HRID 743893 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][CH:7]=1.[N+:16]([O-])([OH:18])=[O:17].S(=O)(=O)(O)O>O>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][C:7]=1[N+:16]([O-:18])=[O:17]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 13942432-(3-Methylphenyl)benzonitrile

生成物 1

HCID 214689052-(3-Methyl-4-nitrophenyl)benzonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-(3-Methylphenyl)benzonitrile (18.1 mmoles, 3.5 g) was added slowly at -5° C. to a mixture of 10 ml nitric acid and 10 ml sulfuric acid. After 5 minutes, the reaction was diluted with cold water. The solid was collected, dissolved in THF. The solution was dried and concentrated. The solid was recrystallized from ether and hexane to yield 2.45 g of 2-(3-methyl-4-nitrophenyl)benzonitrile. (MS)

後処理

  1. customThe solid was collected
  2. dissolutiondissolved in THF
  3. customThe solution was dried
  4. concentrationconcentrated
  5. customThe solid was recrystallized from ether and hexane

出典と根拠

ORDレコード
ord-dbd7b52f29554acc8a2fd831e90ff280
出典データセット
uspto-grants-1996_09
特許番号
US05556981

関連ノート

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