Succinic Acid → (R)-5-(2-Ethylsulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole hemisuccinate
反応式
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[CH2:9]([S:11]([CH2:14][CH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[C:19]2[CH2:25][C@H:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH3:31])(=[O:13])=[O:12])[CH3:10]>C(O)C>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[CH2:9]([S:11]([CH2:14][CH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[C:19]2[CH2:25][C@H:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH3:31])(=[O:13])=[O:12])[CH3:10].[CH2:9]([S:11]([CH2:1][CH2:2][C:3]1[CH:4]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[C:19]2[CH2:25][C@H:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH3:31])(=[O:13])=[O:12])[CH3:10]参加物
4
実験手順
A solution of succinic acid (69 mg) in hot ethanol (3.5 mL) was added slowly with stirring to a solution of (R)-5-(2-ethylsulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole free base (390 mg) in ethanol (3.5 mL). The solution was evaporated and the residue was triturated first with ether and then with ethyl acetate to give the title compound as a solid (375 mg): mp 59°-62° C.: [α]25D =+36° (methanol, c=0.10) Anal Calcd for C18H26N2O2S. 0.5 C4H6O4. 0.25 CH3CO2C2H5. 0.5 H2O: C,59.00; H,7.42; H,6.68. Found: C,59.17; H,7.37; N,6.73.