Methanol → 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester

HRID 744848

反応式

HRID 744848 の反応式
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH:13]([CH3:17])[C:14]([OH:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18]O>S(=O)(=O)(O)O>[CH3:18][O:15][C:14](=[O:16])[CH:13]([CH3:17])[CH2:12][NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10]

参加物

4

反応物 2

HCID 887MethanolHCID 3042743-(((Benzyloxy)carbonyl)amino)-2-methylpropanoic acid

生成物 1

HCID 223644703-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

22.6 g of 3-benzyloxycarbonylamino-2(R,S)-methylpropionic acid are left to stand for 24 hours in 230 ml of methanol with a few drops of concentrated sulfuric acid. The reaction mixture is concentrated by evaporation and the residue is purified by FC (220 g of silica gel, dichloromethane). The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.60.

後処理

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. customthe residue is purified by FC (220 g of silica gel, dichloromethane)

出典と根拠

ORDレコード
ord-cc8983031c1e457db04f9006e1139e60
出典データセット
uspto-grants-1996_09
特許番号
US05559111

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