Water → 2,2'-Bis(trifluoromethyl)-4,4'-dinitrobiphenyl

HRID 745141

反応式

HRID 745141 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[OH2:15]>CN(C)C=O.[Cu]>[F:12][C:11]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:9])=[O:15])=[CH:4][C:3]=1[C:11]([F:12])([F:14])[F:13]

参加物

5

反応物 2

HCID 962WaterHCID 1361982-Bromo-5-nitrobenzotrifluoride

生成物 1

HCID 113724052,2'-Bis(trifluoromethyl)-4,4'-dinitrobiphenyl収率 71%

試薬・触媒・溶媒 2

HCID 23978Copper触媒HCID 6228Dimethylformamide溶媒

実験手順

Activated copper (45 g) was added to a solution of 2-bromo-5-nitro-benzotrifluoride (50 g) in 100 ml of dimethylformamide and the mixture refluxed for 5 hours. The cooled mixture was poured into excess water and the resulting brown precipitate collected by filtration, washed with water and dried. Chromatography over silica gel gave 25 g (71% yield) of ##STR6## 2,2'-bis(trifluoromethyl)-4,4'-dinitro-1,1'-biphenyl, recrystallized as shiny yellow prisms from ether, m.p. 138°-140° C.

後処理

  1. temperaturethe mixture refluxed for 5 hours
  2. filtrationthe resulting brown precipitate collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-b44de8c1673540f19cbc8f51efc90023
出典データセット
uspto-grants-1986_07
特許番号
US04597891

関連ノート

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